Cytotoxicity of 1-dodecyl-3-methylimidazolium bromide on HepG2 cells.

نویسندگان

  • T H Li
  • C Q Jing
  • K L Gao
  • W Y Yue
  • S F Li
چکیده

We evaluated the cytotoxicity of 1-dodecyl-3-methylimidazo-lium bromide ([C12mim][Br]) on HepG2 cells and its influence on plasma membrane permeability. The results showed that [C12mim][Br] inhibited HepG2 cell growth and decreased cell viability in a concentration-depen-dent manner. The results also revealed that [C12mim][Br] exposure induced apoptosis in [C12mim][Br]-treated HepG2 cells. In addition, the results showed that [C12mim][Br] increased membrane permeability in HepG2 cells. These results suggest that plasma membrane permeability may be responsible for apoptosis induced by [C12mim][Br] in HepG2 cells.

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عنوان ژورنال:
  • Genetics and molecular research : GMR

دوره 14 4  شماره 

صفحات  -

تاریخ انتشار 2015